b'Patient Presents with Symptoms of LDYES NOIs it likely to be cancer-related?Review history of cancer treatment: Take medical history and consider the followingSurgeries, e.g., lymph node removal in the differential diagnoses:Radiation therapy LipedemaComplications, e.g., infections of DVT Congenital vascular anomaliesSystemic lymphatic disordersProtein-losing enteropathyExamine the patient LymphangiectasiasLymphaticovenous diseasePediatric lymphaticsFiliarispodoconiosisIs there evidence of tumor, DVT, or cellulitis? Complex Lymphatic AnomaliesGeneralized Lymphatic Anomaly (GLA)Kaposiform Lymphangiomatosis (KLA)YES NO Central Conducting Lymphatic Anomaly (CCLA)Gorhams Stout Disease (GSD)Treat accordinglyLD symptoms persist Examine the patient noting skin condition, degree of pitting, and limb circumference.Secondary LD Utilize the following if available:PerometerBioimpedanceTruncated cone/tape measurementOther serial measurement modality expertiseObtain imaging studies if available:Radionuclide lymphoscintigraphyNear-infrared uorescence lymphographyDirect contrast lymphographyVenographyVenous and lymphatic ultrasonographyMRI imagingMR lymphographyPrimary, non-cancer related LDFigure 4. Algorithm in the differential diagnosis of lymphedema, lipedema, andvascular anomalies inclusive of lymphatic anomalies.| Standardized Approach for the Diagnosis and Management of Lymphedema (LE) and Lymphatic Diseases (LD)|12'