Researchers Page

Researchers

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LE&RN and the National Institutes of Health are dedicated to the research that will bring about new treatments and cures for lymphatic diseases. Here you will find a list of the world's leading lymphatic researchers, their labs, a brief description of their research and a link to their PubMed research database. This page's search engine allows the viewer to search by name, institution or research topic. Researchers can use this page to find potential research collaborations and partners. NIH can use this page for an overview of current research trends and to identify researchers focused on NIH research goals. Click to see current NIH grants for Lymphedema and current NIH grants for the Lymphatic System.

Bertram, Chris

University Of Sydney, Australia

Research Focus: I create numerical models of the mechanics of lymph transport in collecting and initial lymphatic... more
I create numerical models of the mechanics of lymph transport in collecting and initial lymphatic vessels and network. Currently my detailed focus is on 3D finite-element modeling of intravascular lymphatic valves, and on the analysis of imaging data (supplied by U. of Lausanne) to determine the involvement of fluid flow stimuli in the formation of lymphatic valves in embryo.

Burchill, Matthew

University of Colorado-Anschutz Medical Campus

Research Focus: My research focuses on how chronic inflammation drives lymphatic differentiation to regulate disease... more
My research focuses on how chronic inflammation drives lymphatic differentiation to regulate disease pathogenesis.  Specifically, we are examining how transcriptional and functional changes in the liver lymphatics influence immune cell recruitment and activation during chronic liver disease.

Caron, Kathleen

University of North Carolina at Chapel Hill

Research Focus: My research program explores the G protein coupled receptor pathways that regulate lymphatic... more
My research program explores the G protein coupled receptor pathways that regulate lymphatic vascular function during development, adulthood and disease using genetically engineered mouse models, cell culture models, high resolution imaging and genomics approaches.

Dixon, Brandon

Georgia Institute of Technology

Research Focus: Dr. Dixon’s research focuses on the integration of biomechanics, biomedical imaging, and tissue... more
Dr. Dixon’s research focuses on the integration of biomechanics, biomedical imaging, and tissue engineering technologies towards studying the lymphatic system at the molecular, cellular, and tissue-level length scales. His research focuses to improve our basic understanding of the structure-function relationships within lymphatic biology, to improve diagnostics of lymphatic disease, and to develop regenerative strategies to restore lymphatic function.

Dongaonkar, Ranjeet

Texas A&M University

Research Focus: Research in my lab focuses on lymphatic transport and its role in the intestinal and renal function... more
Research in my lab focuses on lymphatic transport and its role in the intestinal and renal function under normal and disease conditions. We employ integrative approaches leveraging a broad expertise in bioengineering, physiology and cell biology to study lymph flow regulation, vascular adaptation, lymphatic pump failure and hastened lymphedema resolution.

Eichmann, Anne

Yale University School of Medicine

Research Focus: We are broadly interested in cellular and molecular mechanisms governing angiogenesis and... more
We are broadly interested in cellular and molecular mechanisms governing angiogenesis and lymphangiogenesis. Our research has revealed Neuropilin2 and Semaphorin3A as novel regulators of lymphangiogenesis (Development 2002, J Cell Biol 2010, Circ Res 2012). We have also found that lymphatic endothelial button junctions in the small intestine control chylomicron uptake, and that zippering (closing) such junctions can prevent chylomicron uptake, thereby rendering mice resistant to diet-induced obesity (Science 2018). Our current research aims at understanding molecular mechanisms controlling development of lymphatic endothelial junctions, with the long-term goal to develop novel treatments to prevent dietary fat uptake and combat obesity.

Iwakiri, Yasuko

Yale School of Medicine

Research Focus: My lab studies lymphatic vascular system in the liver and pancreas.  We also study hepatic... more
My lab studies lymphatic vascular system in the liver and pancreas.  We also study hepatic microcirculation, mechanisms of liver fibrosis/cirrhosis and portal hypertension as well as liver regeneration.

Kerjaschki, Dontscho

Medical University of Vienna

Research Focus: We study the relation of lymphatic function to human diseases on a molecular and cellular basis.... more
We study the relation of lymphatic function to human diseases on a molecular and cellular basis. Currently we focus on the role of lymphatic vessels in metastasis and transplant rejection.

King, Phil

University of Michigan Medical School

Research Focus: My laboratory studies the intracellular signaling mechanisms that regulate the development and... more
My laboratory studies the intracellular signaling mechanisms that regulate the development and function of the lymphatic vascular system. We are particularly interested in understanding how inherited mutations in genes that encode intracellular signaling proteins result in lymphatic disease and how these diseases might be effectively treated. Most recently, we have become interested in understanding how the adaptive immune system promotes the development of secondary lymphedema.

Levit, Rebecca

Emory University, Division of Cardiology

Research Focus: Understanding the natural history and role of lymphatics in heart transplant biology and rejection.... more
Understanding the natural history and role of lymphatics in heart transplant biology and rejection.

May, Michael

University of Pennsylvania

Research Focus: Our research is focussed on understanding the role of pro-inflammatory signaling mechanisms in... more
Our research is focussed on understanding the role of pro-inflammatory signaling mechanisms in regulating the pathophysiological function of blood and lymphatic endothelial cells in inflammatory and immune diseases. We are currently investigating the non-canonical NF-kB pathway in lymphatic endothelial cells using new mouse models that we have generated and we have identified a key role for this mechanism in controlling immune cell migration and lymph node development and function.

Mitchell, Brett

Texas A&M University College of Medicine

Research Focus: Renal lymphatics and hypertension (Recent RO1 grant funded by NIDDK)... more
Renal lymphatics and hypertension (Recent RO1 grant funded by NIDDK)

Padera, Tim

Massachusetts General Hospital/Harvard Medical School

Research Focus: My research focuses on mechanisms of lymphatic vessel function in healthy conditions with regard... more
My research focuses on mechanisms of lymphatic vessel function in healthy conditions with regard to tissue fluid balance and immune responses. We also study the role lymphatic vessels play in a variety of disease settings, including lymphedema, bacterial infections, obesity and sequelae of aging. Finally, we study the role of lymphatic vessels in cancer progression, including how cancer cells growing in lymph nodes can spread further in the body and disrupt anti-tumor immune responses. To accomplish these goals, we have innovated a variety of intravital microscopy tools to allow us to longitudinally follow lymphatic function over the development of a disease process or in response to therapy.

Pawlak, John

University of North Carolina at Chapel Hill

Research Focus: My research is at the intersection of lymphatic and cardiovascular biology, studying endothelial... more
My research is at the intersection of lymphatic and cardiovascular biology, studying endothelial plasticity and programming in specialized vascular beds with an interesting in improving our understanding of mechanisms and signaling pathways that could be targeted for the treatment of vascular diseases.

Rutkowski, Joseph

Texas A&M University College of Medicine

Research Focus: The Rutkowski Lab is interested in how changes in lymphatic vessel biology and physiology impact... more
The Rutkowski Lab is interested in how changes in lymphatic vessel biology and physiology impact disease progression in conditions of chronic tissue inflammation. Ongoing studies are identifying novel roles for lymphatics in obesity, diabetes, hypertension, lymphedema, and lipedema, in tissues from adipose tissue to the kidney. How lymphatics regulate the inflammatory response is a common thread in the lab’s work.

Scallan, Josh

University of South Florida

Research Focus: The laboratory of Dr. Joshua Scallan is focused on studying the mechanisms underlying 1) the... more
The laboratory of Dr. Joshua Scallan is focused on studying the mechanisms underlying 1) the regulation of lymphatic vessel permeability (i.e. barrier function), and 2) the embryonic formation and postnatal maintenance of lymphatic valves. Specifically, we hypothesize that mechanotransduction signaling events that begin at cell-cell junctions regulate both lymphatic permeability and valve development. We employ a unique combination of physiological and genetic approaches to answer these questions, including knockout and transgenic models.

Shawber, Carrie

Columbia University Medical Center

Research Focus: I am developmental lymphatic vascular biologist whose research is focused on lymphatic vascular... more
I am developmental lymphatic vascular biologist whose research is focused on lymphatic vascular development and pathologies. My lab is built around the premise that by understanding the genetics and signaling pathways that govern proper lymphatic vessel formation and maintenance, we can improve diagnosis, monitoring, and treatment of lymphatic disorders and diseases.

Tamburini, Beth

University of Colorado Anschutz Medical Campus

Research Focus: We study the interaction between the lymphatic endothelium and immune cells across organ systems. ... more
We study the interaction between the lymphatic endothelium and immune cells across organ systems.  Specifically we are interested in how the lymphatic endothelium promotes tissue homeostasis and how specific factors can contribute to lymphatic dysfunction.