Other Grants & Awards Programs
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Trans-Agency Blood-Brain Interface Program (R61/R33 - Clinical Trials Not Allowed)
The purpose of this Funding Opportunity Announcement (FOA) is to support high risk/high reward research on the blood/vascular component and regulation of the neurovascular-blood unit (a.k.a., Blood-Brain Barrier; BBB) in normal and pathological states to create enhanced/modified platforms that more closely model the human BBB. Research addressing vascular, hemostatic, hematopoietic, and/or immune cell interaction across the Blood-Brain Interface is of particular interest. This initiative will serve to stimulate the development of a new field of science and re-define the neurovascular unit to also include the blood/vascular component to develop the next generation of pre-clinical human cellular model systems of the human BBB to complement research currently based on animal models.
For application instructions and more information, please visit https://grants.nih.gov/grants/guide/rfa-files/RFA-HL-20-021.html.
Open Date (Earliest Submission Date): September 17, 2019
Letter of Intent Due Date(s): 30 days prior to the application due date
Application Due Date(s): December 2, 2019, October 19, 2020; All applications are due by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on the listed date(s).Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
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Patient-Centered Outcomes Research Institute
PCORI funds research into conditions that affect large numbers of people across a range of populations; conditions that place a heavy burden on individuals, families, specific populations, and society; and rare diseases, which are difficult to study. PCORI funds research through organizations and not individuals.
PCORI funds research that offers patients and caregivers the information they need to make important healthcare decisions. Our scientific research portfolio is divided among two programs, which together reflect our National Priorities for Research. Each program leads the development of PCORI Funding Announcements that may be either broad calls for applications or targeted to specific topics. These programs also participate in the selection of awards and oversee the projects as they progress.
In addition, the Evaluation and Analysis program provides evaluation expertise, while the Engagement program gives patients, caregivers, clinicians, and other healthcare stakeholders opportunities for meaningful involvement in all our activities.
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Rare Disease Cohorts in Heart, Lung, Blood and Sleep Disorders (UG3/UH3 Clinical Trial Not Allowed)
The purpose of this FOA (#RFA-HL-20-014) is to fund research centers that will establish longitudinal cohorts in rare HLBS diseases to investigate unaddressed research questions using epidemiologic study designs and methods that are appropriate for conditions affecting fewer than 200,000 persons in the US. These observational cohort studies should be designed to provide an evidence base for future interventional studies, including clinical trials; for developing better diagnostics than those that are currently available; for answering early translational questions; or for broader implementation of guidelines for managing these diseases.
This program will provide opportunities to advance rare disease research using genetics and deep phenotyping to characterize the disease and to identify disease sub-types; to use data science methods that integrate clinical and patient-reported outcomes with laboratory, imaging, environmental and -omics data to understand the natural history of disease; to generate data that differentiate patients with the same morphological phenotype but different genetic mutations and severity of outcomes; to elucidate genotype-phenotype interactions and multisystem phenotyping to develop reliable and valid predictive tools to determine who will respond to which treatments and when to intervene; and to encourage innovative methods such as telemedicine to include participants with rare diseases located in remote locations.
This initiative will allow applicants to study rare or related rare diseases, disorders, conditions or syndromes together based on pathogenesis, affected biochemical, cellular or physiological features or organ system involvement. Studying related rare diseases within the same cohort could help understand the nuances, and knowledge gained from one disease could accelerate the advances in related diseases. For example, investigators may propose to study hemoglobin disorders rather than only sickle cell anemia or thalassemia.
For application instructions and more information, please visit https://grants.nih.gov/grants/guide/rfa-files/RFA-HL-20-014.html.
Open Date (Earliest Submission Date): May 18, 2019
Letter of Intent Due Date(s): 30 days prior to the application due date
Application Due Date(s): June 18, 2019, June 17, 2020 by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on these dates.Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
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DOD’s Congressionally Directed Medical Research Programs (CDMRP) - BCRP Pre-Announcements
Last year researchers looking at the intersection of lymphedema and breast cancer were encouraged to compete for funding opportunities through the CDMRP’s Breast Cancer Research Program (BCRP). Please see the information below in this regard.
The Fiscal Year 2019 (FY19) Defense Appropriation Act provides funding for the peer reviewed programs managed by the Department of Defense (DOD) office of Congressionally Directed Medical Research Programs (CDMRP). Recently released pre-announcements may be found at http://cdmrp.army.mil/pubs/press/press to allow investigators time to plan and develop ideas for submission to the anticipated FY19 funding opportunities.
FY19 funding opportunities are anticipated to be released in January 2019 for the following programs:
Breast Cancer Research Program
Ovarian Cancer Research Program
Descriptions of each of the anticipated funding opportunities, eligibility, key mechanism elements, and funding can be found in the respective Program pre-announcement. FY19 pre-announcements can be found in the CDMRP home page features at http://cdmrp.army.mil.
Researchers investigating the intersection of lymphedema and breast cancer may be interested in the following grant opportunities recently released.
DOD
Department of Defense
Dept. of the Army—USAMRAA
DoD Breast Cancer, Innovator Award Synopsis 1
https://www.grants.gov/web/grants/view-opportunity.html?oppId=312196
DOD
Department of Defense
Dept. of the Army—USAMRAA
DoD Breast Cancer, Breakthrough Fellowship Award Synopsis 1
https://www.grants.gov/web/grants/view-opportunity.html?oppId=312197
DOD
Department of Defense
Dept. of the Army—USAMRAA
DoD Breast Cancer, Breakthrough Award Level 4 Synopsis 1
https://www.grants.gov/web/grants/view-opportunity.html?oppId=312198
DOD
Department of Defense
Dept. of the Army—USAMRAA
DoD Breast Cancer, Era of Hope Scholar Award Synopsis 1
https://www.grants.gov/web/grants/view-opportunity.html?oppId=312195
DOD
Department of Defense
Dept. of the Army—USAMRAA
DoD Breast Cancer, Distinguished Investigator Award Synopsis 1
https://www.grants.gov/web/grants/view-opportunity.html?oppId=312176DOD
Department of Defense
Dept. of the Army—USAMRAA
DoD Breast Cancer, Breakthrough Award Levels 1 and 2
Synopsis 1
https://www.grants.gov/web/grants/view-opportunity.html?oppId=312177DOD
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Department of Defense
Dept. of the Army—USAMRAA
DoD Breast Cancer, Breakthrough Award Level 3 Synopsis 1
https://www.grants.gov/web/grants/view-opportunity.html?oppId=312178 -
DOD’s Congressionally Directed Medical Research Programs (CDMRP) - PRMRP Grant Opportunities
Peer Reviewed Medical Research Program (PRMRP) Grant Opportunities. – PRMRP funds medical research for a list of conditions and diseases that have been identified by Congress as disproportionately affecting military personnel. LE&RN will be working over the course of this year to include “lymphatic diseases” to this list.
This year’s PRMRP includes “burn pit exposures” and “vascular malformations.” Any researchers looking at this connection between burn pit exposures and the onset of lymphedema should look at the opportunities below. Researchers who are working on research involving vascular or lymphatic malformations may also find funding through these opportunities. Researchers are also encouraged to apply for funding through the designation of vascular malformations as this may encompass vascular anomalies of only veins, only lymph vessels, both veins and lymph vessels, or both arteries and veins.
(https://www.hopkinsmedicine.org/interventional-radiology/conditions/malformations/index.html)LE&RN is working to include “lymphatic diseases” as eligible for study through the fiscal year (FY) 2020 PRMRP and this will definitely improve the ability of researchers to compete successfully for this funding, but the categories above should be seen as an opportunity for researchers to get their foot in the PRMRP’s door.
DOD
Department of Defense
Dept. of the Army—USAMRAA
CDMRP PRMRP Investigator-Initiated Research Award Synopsis 1
https://www.grants.gov/web/grants/view-opportunity.html?oppId=312036
DOD
Department of Defense
Dept. of the Army—USAMRAA
CDMRP PRMRP Technology/Therapeutic Development Award Synopsis 1
https://www.grants.gov/web/grants/view-opportunity.html?oppId=312037
DOD
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Department of Defense
Dept. of the Army—USAMRAA
CDMRP PRMRP Discovery Award
Synopsis 1
https://www.grants.gov/web/grants/view-opportunity.html?oppId=312033
DOD
Department of Defense
Dept. of the Army—USAMRAA
CDMRP PRMRP Clinical Trial Award Synopsis 1
https://www.grants.gov/web/grants/view-opportunity.html?oppId=312034
DOD
Department of Defense
Dept. of the Army—USAMRAA
CDMRP PRMRP Focused Program Award Synopsis 1
https://www.grants.gov/web/grants/view-opportunity.html?oppId=312035 -
Lymphatics in Health and Disease in the Digestive System (R01 Clinical Trial Not Allowed)
The purpose of this Funding Opportunity Announcement is to invite applications that investigate aspects of lymphatic vessel physiology, development and pathophysiology related to health and diseases of the digestive system. Studies to understand the factors that control local lymphatic vessel functional anatomy and physiology and development during health or disease in this system and its organs, and the mechanisms by which alterations of lymphatic vessel function affect organ function, are of interest. However, studies with the major focus on immune mechanisms, role of lymphatics in cancer metastasis and study of lymphatic vessels in organs other than those from the digestive system will not be considered responsive.
NIDDK intends to commit $1,000,000 in FY 2018 to fund up to 3 R01 awards. Application budgets are limited to $250,000 direct costs per year exclusive of subcontracts F&A. The maximum project period is 5 years.
For application instructions and more information, please visit https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-18-021.html.
Open Date (Earliest Submission Date) - January 21, 2019
Letter of Intent Due Date(s) - January 21, 2019
Application Due Date(s) - February 21, 2019, by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on this date.
Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
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Clinical Trial Readiness for Rare Diseases, Disorders and Syndromes (R21-Clinical Trial Not Allowed)
This Funding Opportunity Announcement (FOA) invites researchers to submit applications for support of clinical projects that address critical needs for clinical trial readiness in rare diseases. The initiative seeks applications that are intended to facilitate rare disease research by enabling efficient and effective movement of candidate therapeutics or diagnostics towards clinical trials, and to increase their likelihood of success through development and testing of rigorous biomarkers and clinical outcome assessment measures, or by defining the presentation and course of a rare disease to enable the design of upcoming clinical trials.
Purpose: Attaining effective therapies for rare diseases is challenging due to their low prevalence resulting in fewer patients, clinicians, researchers, and resources compared to common diseases. This leads to gaps in our understanding of a rare disease’s natural history, and a dearth of suitable biomarkers or clinical outcome measures, or of other components needed to design, conduct, and interpret rigorous clinical trials.
The Office of Rare Diseases Research (ORDR) within the National Center for Advancing Translational Sciences (NCATS) along with the Institutes and Centers (ICs) listed in Part I at the National Institutes of Health (NIH) intend to facilitate rare disease research by enabling efficient and effective movement of candidate therapeutics or diagnostics towards clinical trials, and to increase their likelihood of success through development and testing of rigorous biomarkers and clinical outcome assessment measures, or by defining the presentation and course of a rare disease to enable the design of upcoming clinical trials.
For application instructions and more information, please visit https://grants.nih.gov/grants/guide/pa-files/PAR-18-953.html.
Open Date (Earliest Submission Date) - December 07, 2018
Letter of Intent Due Date(s) - 30 days prior to receipt date
Application Due Date(s) - January 7, 2019, June 10, 2019, October 24, 2019, June 8, 2020, October 26, 2020, June 7, 2021, October 25, 2021, by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on these dates.Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
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Clinical Trial Readiness for Rare Diseases, Disorders and Syndromes (R03-Clinical Trial Not Allowed)
This Funding Opportunity Announcement (FOA) invites researchers to submit applications for support of clinical projects that address critical needs for clinical trial readiness in rare diseases. The initiative seeks applications that are intended to facilitate rare disease research by enabling efficient and effective movement of candidate therapeutics or diagnostics towards clinical trials, and to increase their likelihood of success through development and testing of rigorous biomarkers and clinical outcome assessment measures, or by defining the presentation and course of a rare disease to enable the design of upcoming clinical trials.
Purpose: Attaining effective therapies for rare diseases is challenging due to their low prevalence resulting in fewer patients, clinicians, researchers, and resources compared to common diseases. This leads to gaps in our understanding of a rare disease’s natural history, and a dearth of suitable biomarkers or clinical outcome measures, or of other components needed to design, conduct, and interpret rigorous clinical trials.
The Office of Rare Diseases Research (ORDR) within the National Center for Advancing Translational Sciences (NCATS) along with the Institutes and Centers (ICs) listed in Part I at the National Institutes of Health (NIH) intend to facilitate rare disease research by enabling efficient and effective movement of candidate therapeutics or diagnostics towards clinical trials, and to increase their likelihood of success through development and testing of rigorous biomarkers and clinical outcome assessment measures, or by defining the presentation and course of a rare disease to enable the design of upcoming clinical trials.
For application instructions and more information, please visit https://grants.nih.gov/grants/guide/pa-files/PAR-18-952.html.
Open Date (Earliest Submission Date) - December 07, 2018
Letter of Intent Due Date(s) - 30 days prior to the application due date
Application Due Date(s) - January 7, 2019, June 10, 2019, October 24, 2019, June 8, 2020, October 26, 2020, June 7, 2021, October 25, 2021, by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on these dates.Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
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Lymphatic researchers needed for NIH Study SectionsNIH has requested that LE&RN assemble and deliver to NIH a list of lymphatic researchers who are willing to serve on NIH Study Sections. They have identified the following three Study Sections that review lymphatic grant proposals:
* Hypertension and Microcirculation (HM) Study Section reviews applications dealing with propulsion of lymph, lymphatic tone, and pathogenesis of lymphedema with more focus on functional studies; sometimes reviews applications about the lymphatic system in infection and inflammation depending on the outcome of research, namely whether focused on lymphatics or infection.
* Immunity and Host Defense (IHD) and Innate Immunity and Inflammation (III) Study Sections may review applications that address lymphatic role in infection.
* Cardiovascular Differentiation and Development (CDD) Study Section reviews applications involving lymphatic development, lymphangiogenesis, and lymphedema focusing on structure.If you are willing to serve on one or more of the above-identified NIH Study Sections, please contact LE&RN at LERN@LymphaticNetwork.org with the following information:
* Name
* Affiliation
* Study Section(s) on which you are willing to serve
* In 50 words or less, your qualifications for each Study Section selected
* Include CVInvestigators will not be able to review their own research or research on which they are collaborators. However, this will not prevent your research from being reviewed by the Study Section. Per NIH: If a researcher is on a Study Section and has an application, his or her application is reviewed by a special emphasis panel. This is a common practice that happens all the time. This should not be an obstacle to joining a Study Section.
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Online Partnership to Accelerate Research
OnPAR (Online Partnership to Accelerate Research) is a matchmaking platform where applicants and non-government funders come together. Leidos Health’s Life Sciences has partnered with NIH and other funding organizations to accelerate the biomedical research and development enterprise by matching high-scoring unfunded applications with private biomedical foundations and/or industries seeking to fund promising research via OnPAR (e.g., for NIH these would be applications within the 30th percentile but are beyond the funding cutoff).
OnPAR has member organizations and matches the unfunded applications with the funding organization. For more information, please visit https://onpar.leidosweb.com/.
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